Fidji Simo Exits OpenAI AGI Role Due to POTS Health Battle

Fidji Simo is stepping down from her full-time role as CEO of AGI Deployment at OpenAI due to health issues. She will transition to a part-time adviser role. Simo has postural orthostatic tachycardia syndrome, known as POTS. This is a neuroimmune condition she has lived with for about seven years. POTS is a disorder affecting the autonomic nervous system, impacting heart rate and blood circulation. Symptoms include dizziness, fatigue, and fainting, especially when standing. Simo managed her condition with medical treatment and lifestyle adjustments. However, a severe flare-up in early 2026 led to a medical leave. Her recovery took longer than anticipated, prompting her decision to reduce her work hours. This situation highlights the challenges of managing chronic health conditions in demanding roles.